- Acute cutaneous lupus
- Chronic cutaneous lupus
- Oral or nasopharyngeal ulcerations
- Nonscarring alopecia
- Synovitis involving two or more joints
- Serositis
- Renal disorder
- Neurologic disorder
- Hemolytic anemia
- Leukopenia or lymphopenia
- Thrombocytopenia
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- ANA level above laboratory reference range
- Anti-dsDNA antibody level above laboratory reference range
- Anti-Sm presence
- Antiphospholipid antibody positive, by any of the following:
-medium or high titer anti-cardiolipin
-positive test for anti-beta-2-glycoprotein
- Low complement
- Direct Coombs’ test in the absence of hemolytic anemia
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