Patients most commonly notice a desaturation of colours.
Ask patient to look at a bright red object with each eye separately, and ask if the colour appears washed out in the affected eye. If so, then ask patient, "If this is 100% red (presenting object to unaffected eye), the how red is this (presenting object to affected eye)".
Colour vision can be more formally assessed using ishihara colour plates, but that will usually be by referral to an ophthalmologist.
Visual fields - Perform confrontation field testing or refer for formal visual field tests by Ophthalmology department (Goldmann or Humphrey visual field tests)
Fundus examination with optic nerve assessment
Neurological assessment
Further investigation
MRI
Referral to neurology
Multiple periventricular white matter lesions on MRI
Source: eyerounds.org. Contributor: Andrew Doan, MD, PhD, University of Iowa.